![]() Other undesirable side effects from SSD use have also been reported, including delayed wound healing, argyria, leucopenia, hepatic and renal toxicity, and allergic contact dermatitis. However, microbial resistance to antibacterial compounds like SSD is becoming an increasing concern. Its efficacy in wound care is based solely on its antibacterial properties. Therefore, silver sulfadiazine (SSD), a well-known bactericidal agent, is currently the gold standard in topical burn treatment and is often utilized for the treatment of second- and third-degree burns. The ideal topical burn treatment should reduce the wound’s bacterial load without hindering the wound-healing process. The goal of burn treatment is to prevent infection because infection delays wound healing. Moreover, non-fatal burn injuries are a major cause of morbidity. In conclusion, increased consideration and emphasis should be placed on using AV to aid the healing of second- and third-degree burns.īurn injuries pose a great burden worldwide and account for approximately 180,000 deaths per year. It would seem that time to healing benefitted those burns in which AV was utilized. The meta-analysis demonstrated that the mean time to wound healing favored AV (RR: -1.34, 95% CI: -1.8 to 0.9, p < 0.001). The studies included both animal and human subjects. A total of eight studies published between 19 reporting healing of second- and third-degree burns using SSD and AV were included in this review. Six were cohort studies and two were randomized controlled trials. Our goal was to report the healing time for these burns using SSD and AV. ![]() Articles meeting the inclusion criteria were screened and carefully analyzed. In July 2020, a systematic review of MEDLINE (Ovid) and PubMed (National Library of Medicine) was performed to identify studies that reported healing of second- and third-degree burns using either SSD or AV. This study evaluated the healing time of second- and third-degree burn wounds between silver sulfadiazine (SSD) and Aloe vera (AV). Burn wounds remain a prevalent problem in the developed and developing world. ![]()
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